Age-related white matter microstructural differences partly mediate age-related decline in processing speed but not cognition
نویسندگان
چکیده
منابع مشابه
Microstructural white matter changes mediate age-related cognitive decline on the Montreal Cognitive Assessment (MoCA).
Although the relationship between aging and cognitive decline is well established, there is substantial individual variability in the degree of cognitive decline in older adults. The present study investigates whether variability in cognitive performance in community-dwelling older adults is related to the presence of whole brain or tract-specific changes in white matter microstructure. Specifi...
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Age-related white matter changes (WMC) are considered manifestation of arteriolosclerotic small vessel disease and are related to age and vascular risk factors. Most recent studies have shown that WMC are associated with a host of poor outcomes, including cognitive impairment, dementia, urinary incontinence, gait disturbances, depression, and increased risk of stroke and death. Although the cli...
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The aim of this study was to assess whether age-related differences in reaction time can be explained satisfactorily in terms of a global age-related differences in processing speed alone. We investigated the age-related differences in simple, discrimination and choice reaction time in 4to 6-year-old children and young adults using approach proposed by Madden et al. and Ridderinkhoff & van der ...
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Age-related white matter changes are common in the elderly and are considered as manifestation of arteriolosclerotic small vessel disease. Most recent studies have shown that the white matter changes are associated with cognitive impairment and dementia, urinary incontinence, gait disturbances, depression and increased risk of stroke and death. Although the clinical phenotypes of the white matt...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2012
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2011.09.001